Cyclosporin H, EvoPure®

Cyclosporin H, EvoPure® is a hydroxylated metabolite of Cyclosporin A. Cyclosporin H (M-1) and other Cyclosporin metabolites have been found to have lower (<10%) immunosuppressant activity than Cyclosporin A. Cyclosporin H has been found to be a potent inhibitor of superoxide anion (O2-) formation by FMLP (N-Formylmethionyl-leucyl-phenylalanine) in human neutrophils.
EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.

Please contact us at for specific academic pricing.

Background

Cyclosporin H (and other cyclosporin A metabolites) have lower immunosuppressant activity but most likely operate under the same mechanism as Cyclosporin A (CsA) described below.
Cyclosporin B (and other cyclosporin A metabolites) have lower immunosuppressive activity but likely operate under the same mechanism as Cyclosporin A described below. After entering a T-cell, Cyclosporin A associates with the cytosolic protein cyclophilin which helps in protein folding. Cyclosporin A binds to cyclophilins and this complex binds another cytosolic protein phosphatase called Calcineurin (protein phosphatase 2B) that dephosphorylates a transcription factor (nuclear factor of activated T-cells, or NF-AT) needed for expression of interleukin 2 (IL-2.). It also blocks the pathway to nitric oxide synthesis via tumor necrosis factor (TNFa) and Interleukin 1a.