Name: Cyclosporin C, EvoPure®
Price: 379.00 USD

- Overview
  - Cyclosporin C, EvoPure® is a hydroxylated metabolite of Cyclosporin A. Cyclosporin C has similar immunosuppressant activity, but lower nephrotoxicity than Cyclosporin A. Cyclosporin C also has antimycotic properties.
    EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Cyclosporin C and other metabolites of Cyclosporin A have lower immunosuppressant activity but most likely operate under the same mechanism as Cyclosporin A. Cyclosporin A immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, Cyclosporin A associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A:cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and T-cell activation.
- Properties
  - CAS Number
    
    59787-61-0
    
    Molecular Formula
    
    C62H111N11O13
    
    Molecular Weight
    
    1218.6 g/mol
    
    Appearance
    
    Colorless prismatic needle
    
    Other Properties
    
    Source: Tolypocladium Inflatum
    Water Content (Karl Fischer): 3.0%
    Heavy Metals: ≤0.02%
    Melting Point: 152-155 °C
    Purity Level: ≥95.0%
    
    Storage
    
    -20 °C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Cyclosporin metabolites can be used to study toxicity and immunosuppressant activity in various in vitro assays and experiments.