Name: Ceftolozane Sulfate, Stabilized with Arginine
Price: 363.00 USD

- Overview
  - Ceftolozane Sulfate, Stabilized with Arginine is a broad-spectrum, fifth-generation cephalosporin with bactericidal activity. It can be used in biopharma research for impurity profiling and chemical stability testing. It can also be used for penicillin binding protein (PBP) binding profiles and infection models. The product is stabilized with the auxilliary additive α-amino acid L-arginine to enhance stability.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Ceftolozane Sulfate is a 3'-aminopyrazolium cephalosporin. Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases such as AmpC β-lactamase.
- Properties
  - CAS Number
    
    936111-64-2
    
    Molecular Formula
    
    C23H32N12O12S3
    
    Molecular Weight
    
    764.77
    
    Solubility
    
    Soluble in DMSO
    
    Other Properties
    
    Source: Semi-synthetic
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Effective against Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa and E. coli.
    
    Microbiology Applications: In a study of P. aeruginosa using murine pulmonary, urinary tract, and burn wound infection models, Ceftolozane's efficacy was comparable or superior to ceftazidime and imipenem with MIC90 of 1 µg/ml. It was highly stable against AmpC β-lactamase, the main resistance mechanism for cephalosporins (Takeda et al, 2007).