Name: Ceftiofur Sodium
Price: 236.00 USD

- Overview
  - Ceftiofur Sodium is the sodium salt of Ceftiofur, a broad-spectrum, third-generation β-lactamase resistant cephalosporin first described in 1987, commonly used in veterinary research applications. Its metabolite (desfurolyceftiofur) also has antibiotic activity. Ceftiofur Sodium is freely soluble in aqueous solution.
    
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    Background
    
    Like β-lactams, Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephalosporins, Ceftiofur is resistant to β-lactamases.
- Properties
  - CAS Number
    
    104010-37-9
    
    Molecular Formula
    
    C19H16N5NaO7S3
    
    Molecular Weight
    
    545.54 g/mol
    
    Appearance
    
    White to grey-yellow powder
    
    Solubility
    
    Freely soluble in aqueous solution
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤3.0%
    PH: 5.5- 7.5
    Assay: ≥95.0% (on dried basis)
    Purity Level: ≥95.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Ceftiofur is a broad-spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria including β-lactamase producing strains.
    
    Microbiology Applications: Ceftiofur Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram -positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC ranges include:
    Salmonella spp. 0.5 µg/mL – 2 µg/mL
    Escherichia coli 0.12 µg/mL – 0.5 µg/mL
    
    Eukaryotic Cell Culture Applications: Ceftiofur was tested on equine bone marrow-derived mesenchymal stromal cells and found to have no overall effect on cell viability (Parker et al, 2011).
    The influence of Ceftiofur Sodium was examined in vitro on the development of bovine oocytes/embryos during oocyte maturation, oocyte fertilization and embryo culture. When oocytes were exposed during oocyte maturation of fertilization, it did not affect embryo development, either at low (10 and 50 µg/ml) or high (100 and 200 µg/ml) concentrations. However, if fertilized were exposed to 50 µg/ml, it retarded embryo development. Therefore, longterm exposure to high doses during post-fertilization adversely affects embryo development (Holyoak et al, 2009).