Name: Ceftezole Sodium
Price: 259.00 USD

- Overview
  - Ceftezole Sodium is the sodium salt of Cefezole. Ceftezole is a first-generation cephalosporin with broad-spectrum antibacterial activity. It is closely related to Cefazolin in chemical structure. It is alpha-glucosidase inhibitor with anti-diabetic properties.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    41136-22-5
    
    Molecular Formula
    
    C13H11N8O4S3 • Na
    
    Molecular Weight
    
    462.46
    
    Appearance
    
    White to pale yellow crystalline powder
    
    Solubility
    
    Water (200 mg/L)
    
    Other Properties
    
    Source: Semi-synthetic
    Purity Level: ≥90.0% (anhydrous basis)
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Broad-spectrum, effective against Gram-positive and Gram-negative species.
    
    Microbiology Applications: Based on a study of 52 clinical isolates, authors found that Ceftezole resistance in Bacterioides fragilis may be due to a decreased affinity for PBP3 (Yotsuji et al, 1988)