Name: Cefpirome Sulfate Solubilized
Price: 348.00 USD

- Overview
  - Cefpirome Sulfate Solubilized is a mixture of Cefpirome Sulfate with anhydrous sodium carbonate that is used to stabilize the pH in aqueous solution. Cefpirome Sulfate is a semisynthetic, broad-spectrum, fourth generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis, and is resistant to β-lactamases. Cefpirome Sulfate is susceptible to degradation in aqueous solutions and optimal stability is pH 4-6. Cefpirome Sulfate Solubilized is soluble in water.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
    The relative lack of cross-resistance between Cefpirome and the third-generation cephalosporins suggests a slightly different mechanism of action of Cefpirome in comparison to the other cephalosporins.
    Due to its compact dipolar structure, Cefpirome can penetrate Gram-negative bacteria more quickly than the other agents (Nikaido et al, 1990).
- Properties
  - CAS Number
    
    98753-19-6 (Cefpirome Sulfate)
    
    Molecular Formula
    
    C22H22N6O5S2·H2SO4 (Cefpirome Sulfate)
    
    Molecular Weight
    
    612.66 (Cefpirome Sulfate)
    
    Appearance
    
    White or slightly yellow crystalline powder
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Source: Mixture
    PH: 5.5-7.5
    Assay: (On Dried Basis): 80.3-89.2% (content of Cefpirome Sulfate)
    Loss on Drying: ≤3.0%
    Identification: Passes test
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefpirome is a broad-spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria. Many Bacteroides, Enterococci, and Haemophilus species have developed resistance to Cefpirome.
    
    Microbiology Applications: Cefpirome is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options . Representative effective ranges include:
    Campylobacter jejuni 0.5 µg/mL – 8 µg/mL
    Klebsiella pneumoniae 0.032 µg/mL – 0.125 µg/mL
    Pseudomonas aeruginosa 2 µg/mL – 32 µg/m
    
    Cancer Applications: Cefpirome was found to be more effective than ceftazidime, aztreonam, timentin, and piperacillin against nosocomially important isolates during in vitro examination of 253 bacterial isolates (Rolston et al, 1986).