Cefathiamidine

- Overview
  - Cefathiamidine is a broad-spectrum first-generation cephalosporin β-lactam antibiotic. It is used for the treatment of respiratory and urinary tract infections, pneumonia, sepsis, and meningitis.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    33075-00-2
    
    Molecular Formula
    
    C19H28N4O6S2
    
    Molecular Weight
    
    472.58
    
    Appearance
    
    White to off-white crystalline powder
    
    Solubility
    
    DMSO (94 mg/ml)
    
    Other Properties
    
    Source: Synthetic
    Purity Level: ≥97.0% (anhydrous basis)
    
    Storage
    
    -20°C (hygroscopic)
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Gram-positive, Gram-negative
    
    Microbiology Applications: Cefathiamidine has a similar antibacterial spectrum as Cefalotin.