Name: Cefamandole Sodium
Price: 272.00 USD

- Overview
  - Cefamandole sodium is a second-generation cephalosporin antibiotic. It is soluble in water, methanol, or DMSO.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    30034-03-8
    
    Molecular Formula
    
    C18H17N6NaO5S2
    
    Molecular Weight
    
    484.48
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    DMSO: SolubleMethanol: SolubleWater: Soluble
    
    Other Properties
    
    Source: Semi-synthetic
    Assay: (HPLC): ≥90.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefamandole is a broad-spectrum cephalosporin targeting a wide variety of Gram-positive and Gram-negative bacteria.
    
    Microbiology Applications: Cefamandole sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    Escherichia coli 0.08 µg/mL – 100 µg/mL
    Klebsiella pneumoniae 0.8 µg/mL – 12.5 µg/mL
    Media Supplements
    Cefamandole can be used as a selective agent in several types of isolation media:
    Legionella CYE Agar - Legionella BMPA-α Selective Supplement