Cefamandole Nafate

- Overview
  - Cefamandole nafate is a second-generation cephalosporin antibiotic that is freely soluble in aqueous solution and sparingly soluble in methanol.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    42540-40-9
    
    Molecular Formula
    
    C19H17N6NaO6S2
    
    Molecular Weight
    
    512.49
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    Methanol: Sparingly soluble
    Water: Soluble
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤2.0%
    PH: 3.5-7.0
    Assay: (On Dried Basis): 810-1000µg/mg
    Identification: HPLC, IR, UV, Flame reaction of Na
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefamandole is a broad spectrum cephalosporin targeting a wide variety of gram positive and gram negative bacteria.
    
    Microbiology Applications: Cefamandole nafate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include: Escherichia coli 0.08 µg/mL – 100 µg/mL Klebsiella pneumoniae 0.8 µg/mL – 12.5 µg/mL

Datasheet

MSDS

Documents

MSDS-EU

Susceptibility and Resistance Data

Cefamandole Nafate

Background

Documents

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