Name: Azlocillin Sodium
Price: 205.00 USD

- Overview
  - Azlocillin Sodium is a broad-spectrum β-lactam antibiotic and semi-synthetic penicillin derived from ampicillin. It is similar to peperacillin and mezlocillin. The compound has broad-spectrum activity and can be used against a number of Gram-positive and Gram-negative bacteria. It has been used to develop novel antibiotic quantitation techniques. Studies have shown that Azlocillin can inhibit Borrelia. burgdorferi, the causal agent of lyme disease.
    Azlocillin Sodium is freely soluble in aqueous solution.
    
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid-encoded ESBLs (Extended Spectrum β-lactamases).
- Properties
  - CAS Number
    
    37091-65-9
    
    Molecular Formula
    
    C20H22N5NaO6S
    
    Molecular Weight
    
    483.47
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    Freely soluble in aqueous solution
    
    Other Properties
    
    Source: Semi-synthetic
    PH: 6.0 - 8.0
    Assay: (On Dried Basis): ≥90.0%
    Loss on Drying: ≤2.5%
    Identification: Passes test
    
    Storage
    
    ≤30°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Azlocillin Sodium is active against Gram-negative bacteria including Pseudomonas aeruginosa, Haemophilus influenzae, and Escherichia coli and Gram-positive bacteria. It also exhibits antipseudomonal activity and has activity against the malarial parasite Plasmodium falciparum.
    
    Microbiology Applications: Azlocillin Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Pseudomonas aeruginosa 0.5 µg/mL – 512 µg/ml
    Escherichia coli 0.03 µg/mL - 2 µg/ml
    In vitro efficacy of Azlocillin (and Cefotaxime) on drug-tolerant persisters was investigated. After screening 7450 chemical compounds, authors found Azlocillin can kill B. burgdorferi (late log phase and 7-10 day old stationary phase). Azlocillin, cefotaxime and Azlocillin in combination with Cefotaxime can also kill in vitro doxycycline-tolerant B. burgdorferi. In vivo, Azlocillin has demonstrated good efficacy against B. burgdorferi in mice models. These findings suggests that Azlocillin can be effective for B. burgdorferi sensu stricto JLB31 and further research is needed to evaluate its potential use for Lyme disease therapy (Pothineni et al, 2020).