Ascomycin

- Overview
  - Ascomycin is an ethyl analog of FK506 with strong immunosuppressant properties.
    
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    Background
    
    Ascomycin inhibits the production of cytokines produced by Th1 and Th2 cells namely IL-2, IL-4, and IL-10. Additionally, ascomycin inhibits mast cell activation, an important component involved in the atopic immune response.
- Properties
  - CAS Number
    
    104987-12-4
    
    Molecular Formula
    
    C43H69NO12
    
    Molecular Weight
    
    792.01
    
    Appearance
    
    White crystalline powder
    
    Solubility
    
    10mg/mL in Methanol - Clear and colorless or faint yellow solution
    
    Other Properties
    
    Source: Streptomyces hygroscopicus
    Water Content (Karl Fischer): ≤1.0%
    Assay: (HPLC): ≥95.0%
    
    Storage
    
    -20°C
    
    * For research use only