Nigericin sodium

- Overview
  - Nigericin sodium is an antibiotic ionophore produced by Streptomyces hygroscopicus. Nigericin is insoluble in water but soluble in methanol and chloroform (10 mg/mL).
    
    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Nigericin sodium acts as an antiporter of H and K ions by exchanging K for H. This ionic imbalance rapidly decreases the intracellular pH.
- Properties
  - CAS Number
    
    28643-80-3
    
    Molecular Formula
    
    C40H67NaO11
    
    Molecular Weight
    
    746.94
    
    Appearance
    
    White to off-white powder
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: One study showed the increased intracellular acidity halted DNA synthesis in Erlich acites carcinoma lending support to use as a chemotherapeutic agent.