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Overview
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SOX-11 which is a member of the SOX (SRY-related HMG-box) family is a transcription factor normallyexpressed in the developing human central nervous system and plays a role in embryonic celldetermination. Studies show that SOX-11 can be used as a marker for mantle cell lymphoma (MCL).Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressivedisease genetically characterized by overexpression of cyclin D1 (CCND1), an important regulator ofthe G1/S phase of the cell cycle, due to the specific translocation t(11;14)(q13;q32).
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