Name: Anti-MadCAM-1 antibody
Price: 833.00 USD

Overview
- Reacts with human mucosal addressin cell adhesion molecules-1 (MAdCAM-1), a key playerin mediating the infiltration of leukocytes into chronically inflamed tissue. MAdCAM-1 is a cell-surface Igsuperfamily member composed of two extracellular Ig domains, followed by a mucin-like domain, atransmembrane domain and a short cytoplasmatic domain. It interacts via its N-terminal Ig domainwith the lymphocyte homing receptor alpha4 beta7, which plays a critical role in forming the gut-associated lymphoid system. MAdCAM-1 promotes the adhesion of T-and B cells, monocytes/macrophages, and potentially eosinophils, basophils, and differentiated mast cells to thevascular endothelium. Mucosal addressin cell adhesion molecule-1 RNA transcripts are predominantlyexpressed in the small intestine, mesenteric lymph nodes, colon and spleen; and are very weaklyexpresssed in human pancreas and brain. The monocolonal antibody 314G8 recognizes a site in theN-terminal Ig domain of MAdCAM-1. The monoclonal antibody 314G8 detects MAdCAM-1 on venulesin the spleen and small intestine.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human
  
  Clone
  
  314G8
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  100 µg purified antibody in Phosphate Buffered Saline containing 0.1% BSA and0.02% sodium azide.
  
  Storage
  
  Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
  
  Concentration
  
  0.1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Mucosal Addressin Cell Adhesion Molecule 1; Madcam-1; Hmadcam-1 (Gene ID:8174; UniProt:Q13477)
  
  * For research use only