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Overview
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Recognizes a protein of 62kDa, identified as PAX‐8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid‐specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX‐8 is expressed in the thyroid (and associated carcinomas), non‐ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX‐8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX‐8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX‐8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.
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