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Overview
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Recognizes an epitope loCated within the first 20 amino acids of Reticulon-1C (NSP-C).RNL-4 reacts with peripheral nerves and ganglia of various tissues and cross-reacts with smoothmuscle cells and myoepithelium. In the central nervous system it reacts with the neurohypophysis andpars intermedia of the pituitary gland, and a weak diffuse staining was observed in neurons of thegranular and molecular layer of the cerebellar cortex, while glial cells, cerebellar medulla and Purkinjecells are negative. Reticulon-1 has been found to indiCate neuronal differentiation and to bedownregulated in neurological pathologies.Immunogen: synthetic peptide of 20 N-terminal amino acid sequence of Reticulon-1C.
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