Name: Anti-Neurofilament antibody
Price: 739.00 USD

- Overview
  - Recognizes a phosphorylated epitope on heavy neurofilament protein (210 kDa) of variousspecies. Antibodies to the various neurofilament subunits are very useful cell type markers since theproteins are among the most abundant of the nervous system, are expressed only in neurons and arebiochemically very stable. Neurofilaments (NFs) are a type of intermediate filaments (IF) expressedalmost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs in mostvertebrates are composed of three different polypeptide chains with different molecular weights ìneurofilament heavy protein (NF-H), medium (NF-M) and light protein (NF-L), which share sequenceand structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexibleextensions that link NFs to each other and to other elements in the cytoplasm.Immunogen: Pellet of porcine brain cold-stable proteins after depolymerization of microtubules.
    
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- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1
    
    Reactivity
    
    human
    
    Clone
    
    NF-01
    
    Immunogen
    
    Pig brain neurofilament protein-enriched fraction after depolymerization of microtubules
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    100 µg purified antibody in Phosphate Buffered Saline containing 15mM sodium azide.
    
    Storage
    
    Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
    
    Concentration
    
    1 mg/ml
    
    Regulatory Status
    
    RUO
    
    * For research use only
- Applications
  - Application
    
    WB; ICC; ICC