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Overview
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Reacts with Aflatoxin B1 and B2, a 55 kDA protein secreted by Aspergillus. The aflatoxins area group of closely related mycotoxins that are widely distributed in nature. The most important of thegroup is aflatoxin B1 (AFB1), which has a range of biological activities, including acute toxicity, teratogenicity, mutagenicity and carcinogenicity. In order for AFB1 to exert its effects, it must beconverted to its reactive epoxide by the action of the mixed function mono-oxygenase enzymesystems (cytochrome P450-dependent) in the tissues (in particular, the liver) of the affected animal.This epoxide is highly reactive and can form derivatives with several cellular macromolecules, includingDNA, RNA, and protein. Cytochrome p450 enzymes may additionally catalyze the hydroxylation (toAFQ1 and AFM1) and demethylation (to AFP1) of the parent AFB1 molecule, resulting in products lesstoxic than AFB1. Conjugation of AFB1 to glutathione (mediated by glutathione Stransferase) and itssubsequent excretion is regarded as an important detoxification pathway in animals.Aflatoxin B1 is a potent hepatocarcinogenic and mutagenic mycotoxin of Aspergillus flavus.Immunogen: Aflatoxin obtained from Aspergillus.
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