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Overview
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Napsin is a pepsin-like aspartic proteinase in the A1 clan of the AA clade of proteinases. There are twoclosely related napsins, napsin A (NAPSA) and napsin B (NAPSB). Napsin A is involved in processingpropeptide pulmonary surfactant protein B (proSP-B) in the lung. In normal tissue, Napsin A isexpressed in type II pneumocytes of the lung and proximal tubules of the kidney. Napsin A is a usefulmarker for lung adenocarcinoma.
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