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The type I cytokeratin 17 (CK17) shows a peculiar localization in human epithelial appendages including hair follicles, which undergo a growth cycle throughout adult life. Additionally, CK17 is induced, along with CK6 and CK16, early after acute injury to human skin. Predominant expression of CK17and the frequent expression of CK8 and K19, with little CK6/CK16 and CK1/CK10 expression are the characteristic features of basal cell carcinomas (BCC), suggesting that BCC is differentiated towards undifferentiated follicular epithelia, most probably hair bulge cells.
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