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Overview
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P120 catenin is encoded on chromosome 11q11. Alpha-catenin and beta-catenin bind to theintracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. Thecomplex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins celladhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarlyinteract with other cadherins. A deficiency of E-cadherin results in the intracytoplasmic accumulation ofp120 catenin. Lobular carcinoma of the breast shows intracytoplasmic accumulation of p120 cateninwhile ductal carcinoma shows reduced membrane p120 catenin without cytoplasmic accumulation. Ingastric and colonic carcinoma, strong cytoplasmic p120 catenin is associated with discohesiveinfiltrative morphology.
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