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Overview
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Recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reactswith the mutant as well as wild type p53.1 Positive nuclear staining with this antibody has been shownto be a factor in breast carcinoma, lung carcinoma, colorectal carcinoma, urothelial carcinoma, andependymoma.2-8 Anti-p53 positivity has also been used to differentiate uterine serous carcinomafrom endometrioid carcinoma, as well as a marker for intratubular germ cell neoplasia.
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