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Overview
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Oct-4 is a transcription factor that functions in the regulation and maintenance of pluripotency inembryonic stem and primordial germ cells. Oct-4 immunoreactivity has been demonstrated in gonadaland extra-gonadal seminomas, dysgerminomas and embryonal carcinomas. In addition, theimmunohistochemical detection of Oct-4 assists in the evaluation of intratubular germ cell neoplasia(IGCN).
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