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Overview
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Nerve growth factor receptor (NGFR), also known as p75NTR, is a 75-kDa glycoprotein member of thetumor necrosis factor (TNF) receptor family essential for embryonic development of the peripheralnervous system. In normal tissue, NGFR is expressed in neural crest derived cells, lymphoid folliculardendritic cells seen in lymph nodes and tonsils, and myoepithelial cells of the breast, prostate, andsalivary gland as well as basal epithelium of the respiratory system. NGFR has been shown to be areliable adjunct marker for melanoma, specifically desmoplastic and spindle cell variants Anti-NGFRlabels myoepithelial cells of the breast and may aid in the differentiation between benign conditions, pre-invasive neoplastic lesions and invasive malignancies of the breast.
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