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Overview
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Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and, despite thescarce evidence for Oct-2 expression in T cells, it has been shown that this factor participates intranscriptional regulation during T-cell activation. Oct-2 activity is dependent on phosphorylation andalternatitive splicing.Various lymphomas are also positive for this marker including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell richB-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and classic Hodgkinlymphoma.
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