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Overview
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CD117, c-kit is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrowstem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety oftumor cells (follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, breast; malignant melanoma, endodermal sinus tumor, and small cell carcinoma) buthas been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, and tumors of smooth muscle origin.
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