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Overview
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CD138, Syndecan 1, is expressed in the late stages of B-cell differentiation with progression towardsplasma cells. It can be used to differentiate lymphoplasmacytic lymphoma from marginal zonelymphoma. ALK+ large B-cell lyphoma (LBCL) usually strongly expresses CD138 whereas lineage-associated markers such as anti-CD20 and anti-CD79a do not stain ALK+LBCL. Anti-CD138 isimmunoreactive with HHV8-associated primary effusion lymphoma even though the lymphoma cellslack the expression of B-cell markers. Anti-CD138 is a good marker to identify and enumerate plasmacells, benign, reactive, or malignant, in bone marrow biopsy specimens.4, 6 CD138 is also expressed inepithelial cells.
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