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Overview
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Reacts with denaturated heavy chain of human HLA-E.HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimerconsisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in themembrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of otherclass I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon oneencodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bindthe peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, andexons 6 and 7 encode the cytoplasmic tail.Immunogen: Recombinant human HLA-E denaturated heavy chain.
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