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Overview
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Recognized native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E.HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on manytypes of the human cells. The published results showed that the antibody cross-reacts with someclassical MHC Class I molecules (HLA-A3, -A11, -B7). However, the recent Workshop I Session on the3rd International Conference on HLA-G (Paris, July 2003) confirmed that the antibody exhibits muchbroader cross-reactivity classical MHC Class I antigens, namely with HLA-A24, -A32, -B8, -B15, -B27, -B35, -B44, -B54, -C3, -C4, -C5, -C7. Immunogen: Bacterially expressed recombinant HLA-E refolded with beta2-microglobulin and peptide.
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