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Overview
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HAO1 is a protein encoded by the HAO1 gene which is approximately 40, 9 kDa. HAO1 is localised to the peroxisome. It is involved in carbon metabolism, glyoxylate metabolism and glycine degradation. It has 2-hydroxy-acid oxidase activity and is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 is expressed in the liver. Mutations in the HAO1 gene may result in primary hyperoxaluria. STJ97395 was developed from clone Mix and was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. The antibody detects endogenous HAO1 protein.
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