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Overview
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Catenin-beta is a protein encoded by the CTNNB1 gene which is approximately 85, 4 kDa. Catenin-beta is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, blood-brain barrier immune cell transmigration and cell junction organization. It is part of a complex of proteins that constitute adherens junctions which are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. It may also be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Catenin-beta is expressed in the nervous system, liver, skin, intestine and heart. Mutations in the CTNNB1 gene may result in colorectal cancer. STJ97420 was developed from clone 4F2 and was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. The antibody detects endogenous Catenin-beta protein.
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