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Overview
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CYCS is a protein encoded by the CYCS gene which is approximately 11, 7 kDa. CYCS is localised to the mitochondrion intermembrane space. It is involved in the TNFR1 pathway, respiratory electron transport and apoptosis modulation and signalling. It is a small heme protein that functions as a central component of the electron transport chain in mitochondria. It associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. It is also involved in the initiation of apoptosis. CYCS is expressed in the nervous system, liver, kidney, heart and muscle. Mutations in the CYCS gene may result in orbital granuloma. STJ97419 was developed from clone 4B10 and was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. The antibody detects endogenous CYCS protein.
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