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Overview
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CYCS is a protein encoded by the CYCS gene which is approximately 11, 7 kDa. CYCS is localised to the mitochondrion intermembrane space. It is involved in the TNFR1 pathway, respiratory electron transport and apoptosis modulation and signalling. It is a small heme protein that functions as a central component of the electron transport chain in the mitochondria. It associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. It is also involved in the initiation of apoptosis. CYCS is expressed in the nervous system, liver, kidney, heart and muscle. Mutations in the CYCS gene may result in thrombocytopenia. STJ98953 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous CYCS.
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