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Overview
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GFAP is a protein encoded by the GFAP gene which is approximately 49, 8 kDa. GFAP is localised to the cytoplasm. It is involved in signalling by ERBB4, the Jak-STAT signalling pathway, neural stem cell differentiation pathways, lineage-specific markers and ERK signalling. It is one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. GFAP is expressed in the cells of the nervous system, kidney, blood, eye and heart. Mutations in the GFAP gene may result in Alexandra disease. STJ96961 was developed from clone 5C8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody binds endogenous GFAP.
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