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Overview
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CD21 (also known as complement receptor 2 (CR2), C3d receptor, or EBV receptor) is a 140 kDamembrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection ofthese cells. The antigen is absent on T-lymphocytes, monocytes, and granulocytes.is useful in the identification of follicular dendritic cell matrix found in normal lymph nodeand tonsillar tissue. This antibody also labels follicular dendritic cell sarcomas. Anti-CD21 is valuable indifferentiating follicular lymphoma with marginal zone differentiation from marginal zone lymphomawith follicular involvement. It also plays a role in distinguishing among nodular lymphocytepredominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-richB-cell lymphoma in combination with other B-cell and T-cell markers.6 Anti-CD21 is also useful inidentifying abnormal follicular dendritic cell pattern in angioimmunoblastic T-cell lymphoma andfollicular T-cell lymphoma.
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