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Overview
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Carcinoembryonic antigen is a protein encoded by the CEACAM5 gene which is approximately 76, 7 kDa. Carcinoembryonic antigen is localised to the cell membrane. It is involved in the metabolism of proteins and hematopoietic stem cell differentiation pathways and lineage-specific markers. It is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signalling. It may also regulate differentiation, apoptosis, and cell polarity and is used as a clinical biomarker for gastrointestinal cancers. Carcinoembryonic antigen is expressed in the intestine, liver, saliva, stomach and lung. Mutations in the CEACAM5 gene may be involved in urachal cancer. STJ96963 was developed from clone 10E1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous Carcinoembryonic antigen proteins.
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Overview
Immunofluorescence analysis of Human-lung-cancer tissue. 1, Carcinoembryonic Antigen monoclonal antibody (10E1) (red) was diluted at 1:200 (4°C, overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).3, Picture B: DAPI (blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B IHC staining of human colon cancer tissue, diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human-liver tissue. 1, Carcinoembryonic Antigen monoclonal antibody (10E1) was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
Anti-Carcinoembryonic Antigen antibody
Anti-Carcinoembryonic Antigen antibody
Catalog Number:
A001052332STJ
Mfr. No.:
STJ96963
Price:
$224
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