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Overview
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CD21 is a protein encoded by the CR2 gene which is approximately 112, 9 kDa. CD21 is localised to the cell membrane. It is involved in complement and coagulation cascades and the 4-1BB pathway. It is a membrane protein that functions as a receptor for Epstein-Barr virus binding on B-and T-lymphocytes. CD21 is expressed in the spleen, lymph nodes, blood, intestine and bone marrow. Mutations in the CR2 gene may result in systemic lupus erythematosus. STJ96962 was developed from clone 2C5 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous CD21 proteins.
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