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Overview
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Recognizes a protein of 120‐80kDa, identified as E‐cadherin. Cadherins comprise a family of Ca2+‐dependent adhesion molecules that function to mediate cell‐cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E‐, N‐ and P‐cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β‐catenin, to regulate cadherin function. E‐ cadherin plays an important role in epithelial cell adhesion. A decreased expression of E‐cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E‐ cadherin +) and lobular (E‐cadherin ‐) breast carcinomas. It may also help in diagnosis of mesothelioma.
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