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Overview
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Ki‐67 antigen is a nuclear, non‐histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki‐67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki‐67 index and the histo‐pathological grade of neoplasms. Assessment of Ki‐67 expression in breast and neuroendocrine tumors shows a correlation between tumor proliferation and diseaseprogression, thus making it possible to differentiate high‐risk patients. Ki‐67 expression may also prove to be importantfor distinguishing between malignant and benign peripheral nerve sheath tumors. Ki‐67 labeling index has been shown to be a prognostic marker in a number of neoplasms including neuroendocrine tumorand breast carcinoma. In general, Ki‐67 is a good marker of proliferating cell populations.
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Overview