Name: Anti-Granzyme B antibody
Price: 331.00 USD

Overview
- Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell‐mediated immune response. Granzyme B is useful as a marker in the identification of NK/T‐cell lymphomas. High percentages of cytotoxic T‐cells have been shown to be an unfavorable prognostic indicator in Hodgkin’s Disease.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2b kappa
  
  Reactivity
  
  human
  
  Clone
  
  ZM66
  
  Immunogen
  
  Recombinant human GZMB protein fragment (around aa 73‐187)
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Granzyme B; C11; Ctla-1; Cathepsin G-Like 1; Ctsgl1; Cytotoxic T-Lymphocyte Proteinase 2; Lymphocyte Protease; Fragmentin-2; Granzyme-2; Human Lymphocyte Protein; Hlp; Sect; T-Cell Serine Protease 1-3e (Gene ID:3002; UniProt:P10144)
  
  * For research use only