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Overview
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Reacts with the 33 kD human serine protease granzyme B. It does not react with humangranzyme A. It is used as a marker for NK-cells and activated cytotoxic T-cells (CTL). This protease islocalized in cytoplasmic granules and gives a granular staining pattern. Granzyme B is involved in targetcell apoptosis during lymphocyte mediated cytotoxicity. Exocytosis of granzyme containing granules inthe cytoplasm of the target cell will lead to induction of DNA fragmentation and apoptosis of the targetcell.The monoclonal antibody stains granzyme B expressing lymphocytes in sections of sublimateformaldehyde as well as formalin fixed paraffin embedded tissues. It does not react with other celltypes.
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