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Overview
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CD5 is a protein encoded by the CD5 gene which is approximately 54, 5 kDa. CD5 is localised to the cell membrane. It is involved in B cell development pathways, hematopoietic stem cell differentiation pathways and lineage-specific markers. This protein falls under the scavenger receptor cysteine-rich superfamily. It is a type-I transmembrane glycoprotein found on the surface of thymocytes, T-lymphocytes and a subset of B-lymphocytes and may act as a receptor in regulating T-cell proliferation. CD5 is expressed in the blood, pancreas, lymph nodes, bone marrow and spleen. Mutations in the CD5 gene may result in thymus cancer. STJ96973 was developed from clone 10G8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous CD5 proteins.
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