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Overview
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Reacts with extracellular (N-terminal) domain of standard CD44 (Phagocyte glycoprotein 1), a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues(leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. CD44is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptorfor hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thusimportant for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator ofmacrophage recruitment in response to pathogens.Immunogen: COS-7 cells (African Green Monkey)
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