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Overview
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CD44, also designated Pgp-1 or H-CAM, is a broadly distributed 85 kD protein. Amongsthaematopoietic cells CD44 is expressed on B and T lymphocytes, monocytes and neutrophils. OtherCD44-positive cell types include epithelial cells, glial cells, fibroblasts and myocytes. This broaddistribution suggest a general role in cell-cell and cell-matrix adhesion. CD44 is involved in T cellactivation and adhesion. Triggering of CD44 increases homotypic T cell aggregation mediated via LFA-1.CD44 is linked to the cytoskeleton. Furthermore CD44 has an accessory role in lymphocyte adhesion tohigh endothelial venules.
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