Name: Anti-CD20 antibody
Price: 632.00 USD

Overview
- Recognizes CD20, a cell surface 33-37 (depending on the degree of phosphorylation) kDanon-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but notstem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of Tlymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells issynchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance(probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intensity of this association depends onextracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor)aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate beforeBCR endocytosis, whereas CD20 remains at the cell surface.Immunogen: Raji human Burkitt's lymphoma cell line.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human
  
  Clone
  
  MEM-97
  
  Immunogen
  
  Raji human Burkitt's lymphoma cell line
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  100 µg of affinity purified antibody in PBS containing 15 mM sodium Azide, pH 7.4.: 1 mg/ml
  
  Storage
  
  Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  B-Lymphocyte Antigen Cd20; B-Lymphocyte Surface Antigen B1; Bp35; Leukocyte Surface Antigen Leu-16; Membrane-Spanning 4-Domains Subfamily A Member 1; Cd Antigen Cd20 (Gene ID:931; UniProt:P11836)
  
  * For research use only