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Overview
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CD15 is a protein encoded by the FUT4 gene which is approximately 59 kDa. CD15 is localised to the Golgi stack membrane. It is involved in glycosphingolipid biosynthesis, mannose type O-glycan biosynthesis and metabolism. It transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It also catalyses the synthesis of the non-sialylated antigen, Lewis x. CD15 is expressed in the blood, bone marrow, lymph node, spleen and nervous system. Mutations in the FUT4 gene may result in liver lymphoma. STJ97007 was developed from clone Q89 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous CD15 protein.
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