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Overview
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CD25 is a protein encoded by the IL2RA gene which is approximately 30, 8 kDa. CD25 is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways in synovial fibroblasts, PEDF induced signalling and the TGF-beta pathway. It is a proteinaceous signalling compound that is a major mediator of the immune response. It controls many different cellular functions including proliferation, differentiation, cell survival and apoptosis but is also involved in several pathophysiological processes. CD25 is expressed in the blood, spleen and lymph nodes. Mutations in the IL2RA gene may result in intermediate uveitis. STJ97009 was developed from clone Q22 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous human CD25 protein.
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Overview