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Overview
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CD41 is a protein encoded by the ITGA2B gene which is approximately 113, 3 kDa. CD41 is localised to the cell membrane. It is involved in RET signalling, apoptotic pathways, the integrin pathway and focal adhesion. This protein falls under the integrin alpha chain family of proteins. It is a cell-surface receptor that exist as a heterodimer of alpha and beta subunits. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. CD41 is expressed in the bone marrow, lung, spleen, blood and heart. Mutations in the ITGA2B gene may result in glanzmann thrombasthenia. STJ97008 was developed from clone Q90 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous human CD41 protein.
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