Name: Anti-Caspase-8 antibody
Price: 224.00 USD

Overview
- Caspase-8 is a protein encoded by the CASP8 gene which is approximately 55, 3 kDa. Caspase-8 is localised to the cytoplasm and is involved in the TNFR1 pathway, dimerization of procaspase-8, activated TLR4 signalling, apoptosis signalling and toll-like receptor signalling pathways. This protein falls under the cysteine-aspartic acid protease family. It pays a role in the programmed cell death induced by Fas and various apoptotic stimuli. Caspase-8 isoform 1, 5 and 7 are expressed in a wide variety of tissues. Mutations in the CASP8 gene may result in a caspase-8 deficiency. STJ97394 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-8 protein.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; mouse; rat
  
  Clone
  
  2G12
  
  Immunogen
  
  Recombinant Protein
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide and 50% Glycerol.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Caspase-8; Casp-8; Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; Cap4; Fadd-Homologous Ice/Ced-3-Like Protease; Fadd-Like Ice; Flice; Ice-Like Apoptotic Protease 5; Mort1-Associated Ced-3 Homolog; Mach [Cleaved Into-Caspase-8 Subunit P18-Caspase-8 Subunit P10] (Gene ID:841; UniProt:Q14790)
  
  * For research use only