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Overview
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ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary.This MAb is specific to CLIP (aa25‐39 of ACTH); does not react with Synacthen (aa1‐24 of ACTH). POMC (pro‐opiomelanocortin or corticotropin‐lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue‐ specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha‐ MSH (Melanocyte Stimulating Hormone), beta‐MSH, gamma‐ MSH, CLIP (corticotropin‐like intermediary peptide), Lipotropin‐ beta, Lipotropin‐gamma, beta‐endorphin and Met‐ enkephalin. ACTH is also produced by cells of immune system (T‐cells, B‐cells, and macrophages) in response to stimuli associated with stress.Anti‐ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH‐producing cells (corticotrophs).It also may react withother tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
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